genetics of neonatal diabetes mellitus

Genetics of neonatal diabetes mellitus.

Genetics and pathophysiology of neonatal diabetes mellitus

Neonatal diabetes mellitus (NDM) is the term commonly used to describe diabetes with onset before 6 months-of-age. It occurs in approximately one out of every 100,000-300,000 live births. Although this term encompasses diabetes of any etiology, it is recognized that NDM diagnosed before 6 months-of-age is most often monogenic in nature. Clinically, NDM subgroups include transient (TNDM) and per...

Molecular Genetics of Diabetes Mellitus

D iabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. DM is a threat to the world population and a global burd...

Neonatal diabetes mellitus.

Diabetes mellitus has many forms. Neonatal diabetes mellitus is one of the rarest, with a reported incidence of 1 in 450,000 live births.1 2 The first case was described by Kitselle (1 852) in his own newborn son, who subsequently died.3 In Northern Ireland, one case might be expected approximately every 16 years; the lastdocumented here was born in 1983.4 Several literature reviews have highli...

Neonatal diabetes mellitus.

Neonatal diabetes mellitus is a rare form of insulin dependent diabetes mellitus that present within the first month of life, lasting at least two weeks and requiring insulin therapy. Intrauterine growth restriction, failure to thrive, fever, dehydration, hyperglycemia and acidosis with or without ketonuria are the clinical features of the disease. We report four cases of neonatal diabetes mell...

The genetics of diabetes mellitus.

Genes play an important role in the development of diabetes mellitus. Putative susceptibility genes could be the key to the development of diabetes. Type 1 diabetes mellitus is one of the most common chronic diseases of childhood. A combination of genetic and environmental factors is most likely the cause of Type 1 diabetes. The pathogenetic sequence leading to the selective autoimmune destruct...